H2N2V1, Main, Exploration, bibRecord, 000492

HLA-DPB1 and HLA Class I Confer Risk of and Protection from Narcolepsy

Identifieur interne : 000492 ( Main/Exploration ); précédent : 000491; suivant : 000493

HLA-DPB1 and HLA Class I Confer Risk of and Protection from Narcolepsy

Auteurs : Hanna M. Ollila ; Jean-Marie Ravel ; Fang Han ; Juliette Faraco ; Ling Lin ; Xiuwen Zheng ; Giuseppe Plazzi [Italie] ; Yves Dauvilliers [France] ; Fabio Pizza [Italie] ; Seung-Chul Hong ; Poul Jennum ; Stine Knudsen [Norvège] ; Birgit Kornum ; Xiao Song Dong ; Han Yan ; Heeseung Hong ; Cristin Coquillard ; Joshua Mahlios ; Otto Jolanki ; Mali Einen ; Isabelle Arnulf [France] ; Birgit Högl [Autriche] ; Birgit Frauscher [Canada] ; Catherine Crowe ; Markku Partinen [Finlande] ; Yu Shu Huang ; Patrice Bourgin [France] ; Outi Vaarala ; Alex Desautels [Canada] ; Jacques Montplaisir [Canada] ; Steven Mack ; Michael Mindrinos ; Marcelo Fernandez-Vina ; Emmanuel Jean Marie Mignot

Source :

American Journal of Human Genetics [ 0002-9297 ] ; 2015-01.

RBID : Hal:hal-02137019

Abstract

Type 1 narcolepsy, a disorder caused by a lack of hypocretin (orexin), is so strongly associated with human leukocyte antigen (HLA) class II HLA-DQA1(∗)01:02-DQB1(∗)06:02 (DQ0602) that very few non-DQ0602 cases have been reported. A known triggering factor for narcolepsy is pandemic 2009 influenza H1N1, suggesting autoimmunity triggered by upper-airway infections. Additional effects of other HLA-DQ alleles have been reported consistently across multiple ethnic groups. Using over 3,000 case and 10,000 control individuals of European and Chinese background, we examined the effects of other HLA loci. After careful matching of HLA-DR and HLA-DQ in case and control individuals, we found strong protective effects of HLA-DPA1(∗)01:03-DPB1(∗)04:02 (DP0402; odds ratio [OR] = 0.51 [0.38-0.67], p = 1.01 × 10(-6)) and HLA-DPA1(∗)01:03-DPB1(∗)04:01 (DP0401; OR = 0.61 [0.47-0.80], p = 2.07 × 10(-4)) and predisposing effects of HLA-DPB1(∗)05:01 in Asians (OR = 1.76 [1.34-2.31], p = 4.71 × 10(-05)). Similar effects were found by conditional analysis controlling for HLA-DR and HLA-DQ with DP0402 (OR = 0.45 [0.38-0.55] p = 8.99 × 10(-17)) and DP0501 (OR = 1.38 [1.18-1.61], p = 7.11 × 10(-5)). HLA-class-II-independent associations with HLA-A(∗)11:01 (OR = 1.32 [1.13-1.54], p = 4.92 × 10(-4)), HLA-B(∗)35:03 (OR = 1.96 [1.41-2.70], p = 5.14 × 10(-5)), and HLA-B(∗)51:01 (OR = 1.49 [1.25-1.78], p = 1.09 × 10(-5)) were also seen across ethnic groups in the HLA class I region. These effects might reflect modulation of autoimmunity or indirect effects of HLA class I and HLA-DP alleles on response to viral infections such as that of influenza.

Url:

https://hal.umontpellier.fr/hal-02137019

DOI: 10.1016/j.ajhg.2014.12.010

Affiliations:

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Le document en format XML

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<author><name sortKey="Hogl, Birgit" sort="Hogl, Birgit" uniqKey="Hogl B" first="Birgit" last="Högl">Birgit Högl</name>
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          <desc>            <address>              <addrLine>6020 Innsbruck</addrLine>
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</hal:affiliation>
<country>Autriche</country>
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</author>
<author><name sortKey="Frauscher, Birgit" sort="Frauscher, Birgit" uniqKey="Frauscher B" first="Birgit" last="Frauscher">Birgit Frauscher</name>
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          <desc>            <address>              <addrLine>3801 University Street Montreal, QC H3A 2B4</addrLine>
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<country>Canada</country>
<placeName><settlement type="city">Montréal</settlement>
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</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
</author>
<author><name sortKey="Crowe, Catherine" sort="Crowe, Catherine" uniqKey="Crowe C" first="Catherine" last="Crowe">Catherine Crowe</name>
</author>
<author><name sortKey="Partinen, Markku" sort="Partinen, Markku" uniqKey="Partinen M" first="Markku" last="Partinen">Markku Partinen</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-148771" status="INCOMING">          <orgName>Department of Clinical Neurosciences</orgName>
          <desc>            <address>              <addrLine>Helsinki</addrLine>
              <country key="FI"></country>
            </address>
          </desc>
        </hal:affiliation>
<country>Finlande</country>
</affiliation>
</author>
<author><name sortKey="Huang, Yu Shu" sort="Huang, Yu Shu" uniqKey="Huang Y" first="Yu Shu" last="Huang">Yu Shu Huang</name>
</author>
<author><name sortKey="Bourgin, Patrice" sort="Bourgin, Patrice" uniqKey="Bourgin P" first="Patrice" last="Bourgin">Patrice Bourgin</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300149" status="VALID">          <orgName>CHU Strasbourg</orgName>
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          </desc>
        </hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Vaarala, Outi" sort="Vaarala, Outi" uniqKey="Vaarala O" first="Outi" last="Vaarala">Outi Vaarala</name>
</author>
<author><name sortKey="Desautels, Alex" sort="Desautels, Alex" uniqKey="Desautels A" first="Alex" last="Desautels">Alex Desautels</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-486288" status="VALID">          <orgName>Hôpital du Sacré-Coeur de Montréal</orgName>
          <desc>            <address>              <addrLine>5400, boul. Gouin Ouest, Montréal (Québec) H4J 1C5</addrLine>
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<country>Canada</country>
</affiliation>
</author>
<author><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name>
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<country>Canada</country>
</affiliation>
</author>
<author><name sortKey="Mack, Steven" sort="Mack, Steven" uniqKey="Mack S" first="Steven" last="Mack">Steven Mack</name>
</author>
<author><name sortKey="Mindrinos, Michael" sort="Mindrinos, Michael" uniqKey="Mindrinos M" first="Michael" last="Mindrinos">Michael Mindrinos</name>
</author>
<author><name sortKey="Fernandez Vina, Marcelo" sort="Fernandez Vina, Marcelo" uniqKey="Fernandez Vina M" first="Marcelo" last="Fernandez-Vina">Marcelo Fernandez-Vina</name>
</author>
<author><name sortKey="Mignot, Emmanuel Jean Marie" sort="Mignot, Emmanuel Jean Marie" uniqKey="Mignot E" first="Emmanuel Jean Marie" last="Mignot">Emmanuel Jean Marie Mignot</name>
</author>
</analytic>
<idno type="DOI">10.1016/j.ajhg.2014.12.010</idno>
<series><title level="j">American Journal of Human Genetics</title>
<idno type="ISSN">0002-9297</idno>
<imprint><date type="datePub">2015-01</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en">              <p>Type 1 narcolepsy, a disorder caused by a lack of hypocretin (orexin), is so strongly associated with human leukocyte antigen (HLA) class II HLA-DQA1(∗)01:02-DQB1(∗)06:02 (DQ0602) that very few non-DQ0602 cases have been reported. A known triggering factor for narcolepsy is pandemic 2009 influenza H1N1, suggesting autoimmunity triggered by upper-airway infections. Additional effects of other HLA-DQ alleles have been reported consistently across multiple ethnic groups. Using over 3,000 case and 10,000 control individuals of European and Chinese background, we examined the effects of other HLA loci. After careful matching of HLA-DR and HLA-DQ in case and control individuals, we found strong protective effects of HLA-DPA1(∗)01:03-DPB1(∗)04:02 (DP0402; odds ratio [OR] = 0.51 [0.38-0.67], p = 1.01 × 10(-6)) and HLA-DPA1(∗)01:03-DPB1(∗)04:01 (DP0401; OR = 0.61 [0.47-0.80], p = 2.07 × 10(-4)) and predisposing effects of HLA-DPB1(∗)05:01 in Asians (OR = 1.76 [1.34-2.31], p = 4.71 × 10(-05)). Similar effects were found by conditional analysis controlling for HLA-DR and HLA-DQ with DP0402 (OR = 0.45 [0.38-0.55] p = 8.99 × 10(-17)) and DP0501 (OR = 1.38 [1.18-1.61], p = 7.11 × 10(-5)). HLA-class-II-independent associations with HLA-A(∗)11:01 (OR = 1.32 [1.13-1.54], p = 4.92 × 10(-4)), HLA-B(∗)35:03 (OR = 1.96 [1.41-2.70], p = 5.14 × 10(-5)), and HLA-B(∗)51:01 (OR = 1.49 [1.25-1.78], p = 1.09 × 10(-5)) were also seen across ethnic groups in the HLA class I region. These effects might reflect modulation of autoimmunity or indirect effects of HLA class I and HLA-DP alleles on response to viral infections such as that of influenza.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>Autriche</li>
<li>Canada</li>
<li>Finlande</li>
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<li>Norvège</li>
</country>
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<li>Occitanie (région administrative)</li>
<li>Québec</li>
</region>
<settlement><li>Montpellier</li>
<li>Montréal</li>
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<name sortKey="Zheng, Xiuwen" sort="Zheng, Xiuwen" uniqKey="Zheng X" first="Xiuwen" last="Zheng">Xiuwen Zheng</name>
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   |texte=   HLA-DPB1 and HLA Class I Confer Risk of and Protection from Narcolepsy
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HLA-DPB1 and HLA Class I Confer Risk of and Protection from Narcolepsy

HLA-DPB1 and HLA Class I Confer Risk of and Protection from Narcolepsy

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